Daily antibiotics may prevent drug-resistant TB

Tuesday, November 24, 2015


New York: Prescribing antibiotic doses once or twice a week for tuberculosis (TB) treatment are more likely to lead to drug resistant strains than daily antibiotic regimens, new research has found.

Elsje Pienaar

Elsje Pienaar

The finding could lead to better treatment of the roughly 10 million people worldwide who fall ill with tuberculosis each year, the researchers said.

“We wanted to address open questions regarding treatment for tuberculosis,” said study first author Elsje Pienaar from University of Michigan in the US.

“First, can we use the antibiotics that we have in a better way? And if we can change the ones that we have in some way, what modifications would be best?,” Pienaar said.

The study looked into how treatments with the standard antibiotics isoniazid and rifampin fare when taken according to different regimens approved by the US Centre for Disease Control.

These include larger doses a few times per week and smaller daily doses.

The computer simulations used in the study showed that daily treatment with both antibiotics is the best way to go, but even then, the drugs have a hard time killing off all of the TB bacteria.

Part of the problem is that bacteria can hide out in tumour-like lesions called granulomas.

Looking for a way to kill these holdouts, the team investigated whether increasing the number of doses would help raise the antibiotic concentrations inside the granulomas.

They found that upping the doses to nine per week, they were able to cut the time until the bacteria were wiped out by about 10 days, on average.

The computer model is based on data from experiments with rabbits and macaque monkeys.

The study was published in the journal BMC Systems Biology.


Categories: Medicine, RESEARCH

Tags: , , , , , ,

  More from Medicine

Safety concerns linger for generic oncology drugs in developing countries

Pharmaceutical industry-sponsored meals associated with higher prescribing rates

Researchers combine drugs to develop a new treatment for human parainfluenza virus

Common painkillers are more dangerous than we think

Stronger evidence found for link between prenatal exposure to paracetamol and the risk of developing asthma

US scientists document trajectory of Zika virus for first time

Comments »

No comments yet.

Name (required)
E-mail (required - never shown publicly)
Your Comment (smaller size | larger size)
You may use <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong> in your comment.