Tag Archives: Perelman School of Medicine

New breast cancer drug may combat other cancers too

New York: A new oral drug whose efficacy in combating breast cancer has been demonstrated alone and in combination with endocrine therapy, also has potential to combat other types of cancer, new research has found.

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Targeting HIV in semen to shut down AIDS

Washington: There may be two new ways to fight AIDS — using a heat shock protein or a small molecule — to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

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Elective surgery associated with lower risk of death than drugs for ulcerative colitis treatment

Washington: Patients over 50 with ulcerative colitis (UC), a chronic disease of the colon, who undergo surgery to treat their condition live longer than those who are treated with medications, according to a new study from the Perelman School of Medicine at the University of Pennsylvania. The results are published in Annals of Internal Medicine.

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Researchers describe new approach to promote regeneration of heart tissue

A team led by Ed Morrisey, a professor of medicine and cell and developmental biology and the scientific director of the Institute for Regenerative Medicine in the Perelman School of Medicine at the University of Pennsylvania, has now shown that a subset of RNA molecules, called microRNAs, is important for cardiomyocyte cell proliferation during development and is sufficient to induce proliferation in cardiomyocytes in the adult heart.

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People who develop kidney stones may face increased bone fracture risk

Washington: People who develop kidney stones may be at increased risk of experiencing bone fractures, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

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Study highlights probability of lung cancer overdiagnosis with low-dose CT screening

Washington: Data from the National Lung Cancer Screening Trial (NLST) — conducted by the American College of Radiology Imaging Network and National Cancer Institute Lung Screening Study — provided researchers the opportunity to investigate the probability that a cancer detected with screening low-dose computed tomography (LDCT) would not have progressed to become life threatening. The results of this investigation published in JAMA Internal Medicine suggest that up to 18 per cent of the cancers detected by LDCT may not have progressed enough to affect patient health if left undetected.

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Two-pronged approach could lead to a universal shot against flu

Washington: Scientists have shown that a combination of immune cells and antibodies could pave the way for a universal vaccine against influenza, says a study.

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Reprogramming cells to fight diabetes

Washington: For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The “reprogramming” of related alpha cells into beta cells might one day offer a novel and complementary approach for treating type 2 diabetes. Treating human and mouse cells with compounds that modify cell nuclear material called chromatin induced the expression of beta cell genes in alpha cells, according to a new study that appears in the Journal of Clinical Investigation.

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Trapping malaria parasites inside host blood cell forms basis for new class of drugs

Washington: One of the most insidious ways that parasitic diseases such as malaria and toxoplasmosis wreak their havoc is by hijacking their host’s natural cellular processes, turning self against self. Researchers from the Perelman School of Medicine, University of Pennsylvania and Johns Hopkins University, led by Doron Greenbaum, assistant professor of pharmacology at Penn, have identified the cell signalling pathway used by these parasites to escape from and destroy their host cells and infect new cells — pointing the way toward possible new strategies to stop these diseases in their tracks. The study appears in Cell, Host and Microbe.

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Study shows underlying connection between “good” cholesterol and collagen in heart health

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