Hip disorder patients treated using stem cells

Sunday, October 21, 2012

Bangalore: A multi-specialty hospital here has successfully used stem cells to treat a hip joint disorder, relieving affected patients from expensive surgery and conservative treatment.

“We have so far treated seven patients, including two non-resident Indians (NRIs), suffering from hip joint disorder using their stem cells and helped them to resume normal life within months,” Live 100 Hospital chairman H N Nagaraj told IANS here.

Known medically as avascular necrosis (AVN), the uncommon disease leads to temporary or permanent loss of blood supply to hip joint bone and causes disorder. If not treated early, the dislocation of the hip bone with joint surface can result in disability. Any serious injury, medications such as steroids, blood coagulation or excessive alcohol can cause blood loss.

“Stem cell therapy has been used for the first time in the world to treat the hip bone disorder by rejuvenating its tissues with the bone marrow of the patient. Stem cells in the marrow of the affected bone are separated from red blood cells and blood plasma through a clinical process and injected into the hip joint of the patient,” Nagaraj said, demonstrating a case study.

The private hospital on the city’s outskirts has tied up with a Pune-based laboratory to harvest the stem cells and transplant them through four injections over four weeks to restore the hip joint function lost due to damage to its cartilage. The stem cells also repair bone cells as they can differentiate between bone and cartilage cells.

“The novel treatment has no bleeding or scar formation as the process does not involve surgery. The patient has to visit our hospital for a day in a week for each of the four injections,” Nagaraj said.

Though the treatment costs a patient Rs 350,000 currently, the hospital hopes to bring it down over time when awareness of the stem cell therapy spreads and more patients opt for the treatment.

The hospital will soon submit the therapy treatment protocol for publication in the Journal of Bone and Joint Surgery (JBJS) and file for international patent and intellectual property rights.

Among the patients treated at the hospital are two NRIs from the United States – Jayadeep Panduranga, 37, and Aishwariya, 18, who could not get relief from shooting pain due to hip disorder despite years of conventional treatment like core decompression.

“Though I underwent core decompression for nine years in California, there was no relief. Stem cell therapy has reduced pain and hip movements are almost normal,” Panduranga told IANS.

Similarly, Aishwariya, an undergraduate in Detroit, suffered pain in the right hip and faced difficulty in moving around.

“I’m able to walk again with a walker,” Aishwariya said.

by Fakir Balaji

Categories: NEWS

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Comment by Dr Bhavuk garg
2012-10-22 07:15:57

We are using stem cells for AVN for more than 3 years now free of cost to our patients at AIIMS and have treated more than 100 patients but it works in occasional patients and that too temporarily . I feel saying cured the disease is not correct and gives false hope to the patients as it does not alter the long term prognosis of disease

Comment by drd
2012-10-22 09:41:56

Editing at aalatimes appears to be very poor….anything that is quoted by a doc is published without verification…..the results here by no means mean cure

Comment by Dr Satish Arolkar
2012-10-22 13:58:57

i have been evaluating the efficacy of Adipose derived regenerative cells for the past 4 years and have the Cytori Celution system in Mumbai. I am excited by the report of your success in the avascular necrosis of the Hip joint and my patient is a 11 yrs girl done 3 months ago. I have Mri records of the same Knee joint arthritis is another area wherein i have reasonable and MRI proven improvement and will be delighted to keep in touch Was in Bengaluru just a fortnight ago for the national conclave on Stem cells and regret not meeting you.

Comment by Dr K A Naryana
2012-10-22 19:41:42

Claiming a cure amounts to Quackery especially in present era of Evidence Based Medicine.

Comment by Dr Subba rao
2012-10-22 22:14:52

Dear Dr bhavuk garg and Dr k a Narayana,

Can please tell me the treatment option
Available for advanced a vascular necrosis of hip in a young patient?

Comment by Bunty
2012-10-23 10:27:14

Dr. Rao

Dr. Bhavuk and Dr. Narayana have commented upon the false hype created by this news. If somebody has done remarkable thing for the first time in the world, why not publish in New England Journal of Medicine? and why publish in newspapers who would publish any news if you pay them some money…

Comment by DR K RAGHU
2012-10-23 13:44:52

As a hematologist, we know stem cells form blood cells and thats why they are useful in treating bone marrow problems. Stem cells used in other settings like spinal cord injury,myocardial infarction or AVN , in this report are all still experimental.
It should be noted that these are not FDA approved therapies.Of course patients want cures and will jump at any thing thrown at them. Even in the US , patients travel to neighbouring Mexico or Brazil to try these therapies.
But to claim cure is premature, unless u show results and publish them in good journals.
But i have to say that stem cell therapy has opened up a new avenue for money making for doctors.going by the claims in the media.

Comment by DR K RAGHU
2012-10-23 13:48:22

I deal with AVN as a hematologist, it occurs in sickle cell anemia and two of my patients with leukemia who were on high dose steroids.The management in ayoung patient, is always core decompression and if it doesnt work it is THR.

Comment by Dr. Nagaraj H.N.
2012-10-23 14:47:11

At our hospital we have not claimed that we have cured AVN, we have certainly treated advanced AVN in 7 patients and all of them are free from pain, restricted movement and their post therapy MRI shows that the cartilage on the affected side has recovered to that of the normal side, all patients are back to normal activity for the past 11 months, long term results are awaited, we are submitting our findings to JBJS.

Dr. Nagaraj

Comment by Dr. Nagaraj H.N.
2012-10-23 14:57:50

Dr. Bhavuk & Dr. Narayana, We are collecting enough data to publish the results on JBJS, meanwhile our protocol on advanced AVN has helped all the 7 patients to live a normal life after suffering for many years with AVN, we will be more than happy to provide the contact details of all these patients, the evidence what you collect from my patients may help many of your patients.
Dr. Nagaraj, Live 100 Hospital

Comment by Dr. Nagaraj H.N.
2012-10-23 15:04:37

Dr. Bhavuk, I agree with you, none of us should claim cure for any disease, we presented our advanced AVN cases having been treated with stem cells & that they are free from symptoms & the evidence of pre & post therapy MRI to the press. The press has carried the message as CURE, as surgeons we can only treat not cure any problem. Dr. Nagaraj

Comment by Editor
2012-10-23 19:31:40

Dr Bhattiprolu Sarangadhara Murthy in an Email to AalaTimes writes:

“It is wrong to say that they are the first to use the techniques. We have been using it for last 2 years. And the Author should be honest enough to admit that it is effective in fiat stage one and two only. The result should be evaluated radiologically, MRI etc. and published after minimum of 5 years with minimum 33 patients for statistically significance. The procedure is already published in varoius international journals.”

Comment by Dr Subba rao
2012-10-23 20:49:28

Dr Raghu are you a hematologist or Orthopaedic can you say that core decompression is the only treatment for Avn in a young patient.kindly check the literature and give your expert open ion.

Comment by Dr. Ramesh Vardhan
2012-10-24 16:32:46

quite often there is hype regarding any thing new , there is also some kind of over enthusiasm, excitement, when something new is attempted . the amount of support aiims is getting is enormous. it looks to me starting from president to prime minster for whom there seems to be only one medical college in india that is a i i m s(why not in assam and west bengal or j&k the home state of health minister) . none of the govt. agencies come out & say that we will start \ have better colleges than aiims. at the most they say we start aiims like medical colleges . why not better. is somebody going to hang them , if they think about better one’s.?.i think it’s high time , the mind set of the politicians \ bureaucrats should change. dr .nagraj go ahead with your work with in the norms \ ethics.
dr. ramesh vardhan

Comment by Bunty
2012-10-24 17:17:24

Dr. Vardan

Before making this comments, kindly check the number of publications in any year by AIIMS as comapred to any other institution in India. Research should be encouraged in all medical colleges, but creating false hype should be discouraged. All are aware of placebo effect and that’s why randomisation is important. Even Ramdev claim on the news channel that he has cured renal failure and cancer and all sorts of illness. But doctors in institution knows the reality when patients comes back with advanced illness.

Comment by drKIRAN
2013-01-16 21:20:00

entirely agree with dr k a naryana and dr raghu – this stem cell therapy is a sham , money making venture . i pity the gullible public going for these treatments .unfortunate but true that one can cure arthritis and avn with stem cells .

pl beware of such therapies .

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